Cissus Quadrangularis: It belongs to the taxonomic group Magnoliopsida and family Vitaceae. Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India. It is commonly known as Veldt Grape or Devil's Backbone. The plant commonly known as “bone setter”- it is referred to as Asthisandhani in Sanskrit and Hodjod in Hindi because of its ability to join bones; It was prescribed in the ancient Ayurvedic texts as a general tonic and analgesic, with specific bone fracture healing properties. This review gives a brief idea about its botanical description, phytochemistry, Osteoblastogenesis activity and its molecular healing mechanisms in osteoporosis; It is showed a promising effect on delaying bone loss of orally administration of CQ for 24 weeks, as indicated by a slower bone remodelling process via a reduction in BTMs; Moringa Oleifera: M. Oleifera is a tropical plant native to northern India, Pakistan, the Himalayan region, Africa, Central America and Arabia and is exceptionally rich in a variety of nutrients and medicinal phytochemicals. Specifically, it contains all the essential amino acids, beta-carotene, vitamin C, potassium, calcium, as well as other smaller micronutrients. M. Oleifera was given to study its effects on the healing process of mandibular fractures. The M. Oleifera intervention showed a decrease in swelling and tenderness and an increase in jaw mobility; Calcium Citrate Maleate: Calcium Citrate Malate has been shown to have several applications such as treating Osteoporosis, Osteomalacia, hypoparathyroidism and certain muscle disorders such as latent tetany. It helps to maintain bone mass and significantly decreases the risk of bone fracture in the elderly; CCM is exceptional in that it confers many unique benefits that go beyond bone health. Unlike other calcium sources that necessitate supplementation be in conjunction with a meal to ensure an appreciable benefit is derived, CCM can be consumed with or without food and delivers a significant nutritional benefit to individuals of all ages. CCM is also recognized as a calcium source that does not increase the risk of kidney stones, and in fact it protects against stone-forming potential. The versatile nature of CCM makes it a convenient and practical calcium salt for use in moist foods and beverages.